CBD is a compound in the cannabis plant that can have several health benefits, such as fighting inflammation. Cannabis has long been proven for its anti-inflammatory properties. However, researchers at ETH Zurich have found that it is not only the well-known psychoactive substances that are responsible for this; a compound that we consume every day in plant nutrients also plays an important role. Pharmacological stimulation of cannabinoid receptors with the potent agonist HU210 also induced a reduction in experimental colitis.
Cannabinoid Receptor 2 Activation Improves DSS-Induced Colitis Through Inflammasome Inhibition NLRP3 in Although THC is the cannabinoid that causes the “high feeling” that many people associate with cannabis, research suggests that CBD may help relieve inflammation, among other things. These data indicated that activation of CB1 and the endogenous cannabinoid system is an early and important physiological step in self-protection of the colon against inflammation. Table 1 Role of major inflammasomes in representative chronic inflammatory disorders together with the known effect of cannabinoids. Therefore, with established evidence suggesting the role of cannabinoids as key regulators of inflammasome signaling, vital cannabinoid moieties (CBD and THC) could be beneficial in alleviating the inflammatory aspects of COVID-19 by blocking inflammasome signaling.
Several studies in recent decades have suggested the potential of cannabinoids to modulate the inflammasome pathway. Selective Cannabinoid Receptor 2 Activation Attenuates Myocardial Infarction By Suppressing Inflammasome In addition, cannabinoids can affect immune responses and host resistance by altering the balance between cytokines produced by helper T cell subsets, Th1 and Th2. Treatment with the transient potential vanilloid receptor antagonist 1 was detrimental to the efficacy of cannabidiol, whereas there was no effect caused by cannabinoid receptor 1 and cannabinoid receptor 2 antagonists. As studies show, not only does cannabis have a positive effect on the domination of inflammation and a myriad of ailments associated with inflammation, but the entourage effect created by the combination of cannabinoids, including THC, gives the person an even better result. On the other hand, a recent study suggests that the use of newly prescribed cannabinoids (nabilone or dronabinol) among older adults with chronic obstructive pulmonary disorder (COPD) was associated with higher rates of adverse events.
The second purpose of this study was to investigate the anti-inflammatory effects of cannabinoids formulated in two different formulations. Therefore, cannabinoids can be considered useful for controlling T1D due to their anti-inflammatory properties. A new peripheral cannabinoid receptor 1 antagonist, AJ5012, improves metabolic outcomes and suppresses inflammation of adipose tissue in obese mice. Cannabis has been shown to have anti-inflammatory effects due to its components, cannabinoids and terpenoids.
